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Dactinomycin‐Induced, Severe Lichenoid Eruption in a Child
Author(s) -
Ridola V.,
Mahé E.,
Fawaz O.,
Galmiche L.,
Patte C.,
Grill J.
Publication year - 2006
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2006.00294.x
Subject(s) - medicine , dermatology , hyperpigmentation , rash , dactinomycin , chemotherapy , biopsy , skin biopsy , surgery , pathology , cycloheximide , microbiology and biotechnology , biology , protein biosynthesis
There is little information in the medical literature about skin rashes associated with dactinomycin in the absence of radiotherapy. We report a 12‐month‐old male child who developed a severe cutaneous reaction that consisted of a widespread pruritic papular eruption associated with fever and a poor general state after dactinomycin administration. Skin biopsy specimen findings confirmed the diagnosis of lichenoid eruption. The rash improved with topical steroid treatment and completely resolved within 1 month with persistence of a residual mild hyperpigmentation. Dactinomycin administration was discontinued for the remaining cycles of chemotherapy.