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Inflammatory Peeling Skin Syndrome Studied with Electron Microscopy
Author(s) -
Tsai Katia,
Valente Neusa Yuriko Sakae,
Nico Marcello Menta Simonsen
Publication year - 2006
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.2006.00290.x
Subject(s) - corneocyte , stratum corneum , electron microscope , medicine , erythema , intracellular , dermatology , pathology , granular layer , cleavage (geology) , desquamation , biology , microbiology and biotechnology , paleontology , physics , fracture (geology) , optics , cerebellum
Peeling skin syndrome is a rare autosomal recessive dermatosis characterized by lifelong continual skin shedding with underlying erythema. We present a 10‐year‐old boy with this disease. Easy peeling of the skin associated with keratotic areas was observed. Microscopic findings included psoriasiformis dermatitis. Cleavage was observed between corneocytes as well as between granular‐corneum cells and within the granular cell layer. Electron microscopic findings included intra‐ and intercellular cleavage of corneocytes and intracellular separation of granular cells. The molecular mechanisms of peeling skin syndrome are discussed.