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Ear Lobe Bilateral Necrosis by Levamisole‐Induced Occlusive Vasculitis in a Pediatric Patient
Author(s) -
Menni Silvano,
Pistritto Grazia,
Gianotti Raffaele,
Ghio Luciana,
Edefonti Alberto
Publication year - 1997
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1997.tb00695.x
Subject(s) - medicine , levamisole , vasculitis , nephrosis , discontinuation , lesion , nephrotic syndrome , necrosis , pathology , surgery , disease
We describe a bullous‐hemorrhagic reaction of the ear lobes in a child with nephrosis after levamisole intake. This drug is used in children as an alternative treatment of corticosteroid‐responsive nephrotic syndrome. Histologic evaluation of a lesion revealed necrotizing vasculitis involving mainly the large vessels of the deep plexus. The lesions disappeared 25 days after discontinuation of treatment.