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Exfoliative Dermatitis Due to Immunologically Confirmed Carbamazepine Hypersensitivity
Author(s) -
Troost Roger J. J.,
Oranje Arnold P.,
Lijnen Raf L. P.,
Benner Robbert,
Prens Errol P.
Publication year - 1996
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1996.tb01249.x
Subject(s) - medicine , carbamazepine , exfoliative dermatitis , dermatology , delayed hypersensitivity , hypersensitivity reaction , contact dermatitis , immunology , allergy , epilepsy , antigen , psychiatry
A 6–year‐old Caucasian girl experienced a generalized erythematous skin rash during carbamazepine therapy. Over the next four days the eruption worsened into erythroderma with fever and generalized lymphadenopathy. Routine laboratory studies revealed increased serum levels of liver enzymes and eosinophilia. Immunologic reactivity to the anticonvulsant carbamazepine and its analogs was investigated both in vivo and in vitro by patch tests and lymphocyte proliferation assays, respectively.