Premium
Neonatal Lupus Erythematosus in an Infant with Turner Syndrome
Author(s) -
Ruas E.,
Moreno A.,
Tellechea O.,
Rocha G.,
Raptista A. Poires
Publication year - 1996
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1996.tb01244.x
Subject(s) - medicine , antibody , turner syndrome , lupus erythematosus , anti nuclear antibody , scalp , dermatology , connective tissue disease , pathology , immunology , pediatrics , autoimmune disease , autoantibody
Neonatal lupus erythematosus (NLE) is characterized by transient, annular cutaneous lesions, congenital heart block, and a variety of systemic or hematologic abnormalities. We describe a white infant girt with onset of skin lesions on the face and scalp at 4 days of age. At age 4 weeks she had generalized, erythematous, scaly, annular skin lesions that underwent spontaneous regression at age 5 months. Her mother had no cutaneous or other lesions, but complement examinations revealed the presence of anti‐Ro(SSA) and anti‐La(SSB) antibodies, and absence of anti‐Sm and anti‐RNP antibodies. Karyotyping revealed Turner syndrome (TS) with 45,XO sex chromosome constitution. Ro(SSA) and La(SSB) antibodies were found, and direct immunofluorescence testing on healthy skin was positive. At age 5 months, follow‐up immunologic examination of the infant had normal results but the mother still had anti‐Ro(SSA) and anti‐La(SSB) antibodies. We believe that this is the first reported case of NLE in association with TS.