Premium
Fox‐Fordyce Disease in Two Prepubertal Girls: Histopathologic Demonstration of Eecrine Sweat Gland Involvement
Author(s) -
Ranalletta Maria,
Rositto Alicia,
Drut Ricardo
Publication year - 1996
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1996.tb01243.x
Subject(s) - medicine , apocrine , hyperkeratosis , dermatology , sweat gland , pathology , biopsy , lesion , keratolytic , sweat
This report presents two prepubertal girls with Fox‐Fordyce disease, The pruritic papules extensively affected the areas where apocrine glands are distributed (axillae, periareolar and Jntermammary zones, pubes, Infraumbilical midline), and also extended to the neck and face near the external angle of the eyes in one child. Analyses of several biopsy specimens showed that the main lesion was a spongiotic vesicle containing inflammatory ceils and keratlnocytes affecting the hair in‐fundibuia and acrosyringia, together, with hyperkeratosis of both adnexa, The cause of the disease remains elusive, but the microscopic findings may explain the good results obtained with keratolytic agents.