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Usefulness of Histopathologic Examination of Thick Scales in the Diagnosis of X‐Linked Dominant Chondrodysplasia Punctata (Happle)
Author(s) -
Yanagihara Makoto,
Ueda Keiichi,
Asano Naomi,
Ozawa Takeshi,
Nakatani Akemi,
Hirose Michiyo
Publication year - 1996
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1996.tb01176.x
Subject(s) - hyperkeratosis , medicine , pathology , physical examination , anatomy , dermatology , surgery
Most patients with X‐linked dominant chondrodysplasia punctata (X‐DCDP) have whorled, thick, or spiky adherent hyperkeratosis on their whole body. Histopathologically, there are large keratotlc plugs of hair follicles where calcium deposits. This is the characteristic finding in this disease. We performed histopathologic examination of skin specimens from two newborn babies with X‐DCDP. The desquamated thick scales from the hyperkeratotic lesions had calcium in the center of the keratotic plugs. Histopathologic examination of thick scales is easy and helpful in diagnosing X‐DCDP.