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Partial Lipodystrophy Associated with Juvenile Dermatomyositis: Report of Two Cases
Author(s) -
Quecedo Esther,
Febrer Isabel,
Serrano Gabriel,
MartinezAparicio Antonio,
Aliaga Adolfo
Publication year - 1996
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1996.tb00728.x
Subject(s) - medicine , juvenile dermatomyositis , acanthosis nigricans , lipoatrophy , dermatomyositis , dermatology , lipodystrophy , connective tissue disease , connective tissue , pathology , insulin , disease , insulin resistance , autoimmune disease , immunology , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load
A 27‐year‐old woman and a 13‐year‐old girl diagnosed with juvenile dermatomyositis in childhood developed clinical findings of partial lipodystrophy 10 years after diagnosis. Exhaustive clinical and laboratory examinations showed an association with other abnormalities: hy‐pertrichosis, steatohepatitis, and an abnormal insulin response to the glucose loading test in the first patient. Hypertrichosis, steatohepatitis, insulin‐resistant diabetes mellitus, and acanthosis nigricans were observed in the second patient. Renal function was normal in both patients. Although a localized form of lipodystrophy has been reported associated with connective tissue disease (connective tissue lipoatrophy), the partial form has been infrequently described in association with juvenile dermatomyositis.