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Congenital Leukemia Cutis Preceding Monoblastic Leukemia by 3 Months
Author(s) -
Monpoux Fabrice,
Lacour Jean Philippe,
Hatchuel Yves,
Hofman Paul,
Raynaud Sophie,
Sudaka Isabelle,
Ortonne Jean Paul,
Mariani Roger
Publication year - 1996
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1996.tb00727.x
Subject(s) - leukemia cutis , medicine , leukemia , pathology , bone marrow , cutis , acute leukemia , skin biopsy , biopsy , dermatology , immunology
We report an infant born with a cutaneous nodular eruption and neutropenia. Skin biopsy specimens revealed an immature dermal infiltrate suggestive of leukemia cutis, but repeated peripheral blood and bone marrow examinations failed to demonstrate malignant cells. The eruption resolved spontaneously. At the age of 3 months, a second occurrence of maculopapular skin lesions led to discovery of an acute monoblastic leukemia with (9;11)(p21–22;q23) translocation. Congenital acute leukemia is a rare disease associated with skin infiltration in 25% to 30% of patients. Usually the diagnosis is easily made by peripheral blood examination and/or bone marrow aspirate. However, skin involvement may precede acute leukemia by several weeks. Although very rare, this event must be kept in mind.