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Congenital Melanoma: A Case Suggesting Rhabdomyogenic Differentiation
Author(s) -
Koyama Teruhisa,
Murakami Motomasa,
Nishihara Osami
Publication year - 1996
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1996.tb00707.x
Subject(s) - desmin , basal lamina , pathology , melanoma , medicine , actin , epithelioid cell , anatomy , immunohistochemistry , biology , microbiology and biotechnology , cancer research , vimentin , ultrastructure
A newborn girl had some subcutaneous masses within a giant congenital melanocytic nevus in the left parietal area. Microscopic examination revealed melanoma. The tumor consisted of two different patterns, being composed partly of epithelioid cells and partly of spindle shaped cells. Immunohistochemically the epithelloid cells showed a positive reaction for HMB‐45 and NKI/C3, and a negative reaction lor desmin and α‐sarcomeric actin. The spindle‐shaped cells showed a negative reaction for HMB‐45 and NKI/C3, and a positive reaction tor desmin and α‐sarcomeric actln. Ultrastructurally the spindle‐shaped cells had some schwannian features, namely, a basal lamina, interdigitating cell processes, and functional complexes. The pathologic findings of our case suggest possible direct rhabdomyogenic differentiation of melanoma cells.