Premium
Acute Graft‐versus‐Host Disease with Unusual Cutaneous Intracellular Vacuolation in an Infant with Severe Combined Immunodeficiency
Author(s) -
Farrell Anne,
Scerri Lawrence,
Stevens Alan,
Millard Leslie G.
Publication year - 1995
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1995.tb00190.x
Subject(s) - medicine , immunodeficiency , intracellular , disease , host (biology) , immunology , graft versus host disease , pathology , immune system , biology , microbiology and biotechnology , ecology
We report an infant with severe combined immunodeficiency (SCID) who had cutaneous manifestations of acute graft‐versus‐host disease (GVHD) due to maternofetal lymphocyte engraftment. Histologic and ultrastructural examinations of the skin revealed intracellular vacuoles resembling lipid droplets in the epidermis and dermis, which is not a recognized feature of acute GVHD or SCID.