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Persistent Erythema Infectiosum‐Like Rash as a Prodrome of Acute Lymphocytic Leukemia
Author(s) -
Lee Seung Min,
Kim Dong Gun,
Bang Dongsik
Publication year - 1994
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1994.tb00571.x
Subject(s) - medicine , prodrome , erythema infectiosum , rash , dermatology , immunology , parvovirus , parvoviridae , psychiatry , virus , psychosis
A 7‐year‐old boy had erythema infectiosum with typical manifestations. over more than 40 days, these lesions showed no sign of regression, and chronic anemia became progressively more severe.Electron microscopic examination performed 20days after onset showed abnormal Sezary‐like lymphocytes. Bone marrow biopsy, which was performed to evaluate the anemia, was consistent with acute lymphocytic leukemia. Persistent parvovirus B 19 infection may be connected with immunosuppression. Therefore, early electron microscopic study and bone marrow biopsy may be helpful for early diagnosis of hematologic malignancies.