Premium
Management of a Young Patient With Xeroderma Pigmentosum
Author(s) -
LealKhouri Susana,
Hruza George J.,
Hruza Luciann L.,
Martin Ann G.
Publication year - 1994
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1994.tb00080.x
Subject(s) - xeroderma pigmentosum , dermabrasion , medicine , dermatology , isotretinoin , carcinogenesis , cancer research , basal cell , dna repair , dna , pathology , genetics , cancer , biology , acne
Xeroderma pigmentosum is a group of rare autosomal recessive disorders with defective DNA repair that provide insight into the basic mechanism of carcinogenesis. It is the best human model linking clinical abnormalities and neoplasla to carcinogen exposure. We describe a patient with xeroderma pigmentosum and numerous basal cell carcinomas, squamous cell carcinomas, and melanomas treated with radiation therapy, Mohs micrographic surgery, dermabrasion, and isotretinoin prophylaxis.