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Partial Improvement of Olmsted Syndrome With Etretinate
Author(s) -
Ueda Masato,
Nakagawa Koichi,
Hayashi Kazuhiro,
Shimizu Ryosuke,
Ichihashi Masamitsu
Publication year - 1993
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1993.tb00404.x
Subject(s) - medicine , keratoderma , etretinate , palmoplantar keratoderma , keratolytic , dermatology , palm , surgery , muscle contracture , hyperkeratosis , physics , quantum mechanics , psoriasis
An 11‐year‐old Japanese boy with Olmsted syndrome was seen at our clinic. He had a sharply marglnated, painful keratoderma with a red border on his palms and soles. Flexion contractures of the fingers were also observed. Hyperkeratotic plaques were present below the lower lip, on the elbows and knees, and In the sacral area. Localized alopecia, leukokeratosis on the tongue, shortness of stature, and laxity of the large joints corresponded to the clinical features of Olmsted syndrome. Treatment with etretinate was effective for the palms and fingers, but resulted in no improvement of the keratoderma of the soles. Because of periosteal thickening of the tibia, presumably caused by etretinate, therapy was terminated one year after it began.