Focal Epithelial Hyperplasia: Heck Disease

Two sisters of Mexican ancestry had focal epithelial hyperplasb (FEH). The lesions on the oral mucosa of the older child were initially misinterpreted as representing sexual abuse. Microscopic evaluation of a hematoxylin and eosln‐stained section from a lower lip papule demonstrated the histologic features of FEH. Although human papllloma‐virus (HPV) type 13 and HPV32 have been most consistently present In FEH lesions, types 6,11,13, and 32 were not detected In the paraffin‐embedded tissue specimen of our patient using an in situ hybridization technique. The lesions persisted or recurred during management using destructive modalities; subsequently, they comptetety resolved spontaneously.