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Atopic Dermatitis: Studies of Skin Permeability and Effectiveness of Topical PUVA Treatment
Author(s) -
Ogawa Hideoki,
Yoshiike Takashi
Publication year - 1992
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1992.tb00638.x
Subject(s) - medicine , stratum corneum , dermatology , atopic dermatitis , adverse effect , pathology
Uttraviolet light is effective treatment for patients with atoptc dermatitis that is resistant to conservative therapy, or complicated by adverse effects of extended steroid use. We designed a protocol using topical paoraton chemotherapy with ultraviolet A (PUVA) to treat atopic dermatitis In 114 patients. Clinical results were excellent, with complete clearing in 50% of patients receiving dally treatment. Histologic and immunologic values correlated with the clinical response, including reduced epidermal thickness, and decreased numbers of epidermal Lang‐erhans cells and dermal mast and mononuclear cell Infiltrates. The pattern of keratin 14‐positive keratinocytes returned toward normal. In addition, the water‐holding capacity of the stratum corneum increased to near normal levels. We also studied stratum comeum permeability in lesional and nonlesional skin using the dimethyl sulfoxide wheallng test and theophy line absorption studies. Compared wtth controls, permeabuIity was markedly increased in lesional skin and mildly Increased In nonlesional skin in patients with atopte dennatatis. These results suggest that Immune abnormalities and barrier dysfunction participate in the patho genesis of atopic dermatitis.