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Comparison of Crotamiton 10% Cream (Eurax) and Permethrin 5% Cream (Elimite) for the Treatment of Scabies in Children
Author(s) -
Taplin David,
Meinking Terri Lynn,
Chen Joaquin A.,
Sanchez Regulo
Publication year - 1990
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1990.tb01078.x
Subject(s) - scabies , permethrin , medicine , dermatology , biology , pesticide , agronomy
Permethrin 5% cream (Elimite) was approved as a treatment for scabies by the U.S. Food and Drug Administration in September 1989. in a doubie‐biinded, randomized study, it was compared with crotamiton 10% cream (Eurax) for the treatment of scabies in children 2 months to 5 years of age. Two weeks after a singie overnight treatment, 14 (30%) of 47 chiidren were cured with permethrin 5% cream, in contrast to oniy 6 of 47 (13%) of subjects treated with Eurax. Four weeks after treatment the figures were 89% and 60% cured for the two agents, respectively. In 10 of the 19 patients whose treatment failed, the condition became worse after therapy. The difference in efficacy in favor of permethrin was significant (P = 0.002). That agent also demonstrated greater effectiveness in reducing pruritus and secondary bacterial infections. Eilmite offers a safe, efficacious, and cosmetically elegant aiternative to Eurax in the treatment of scabies in chiidren.