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Photochemotherapy of Dominant, Diffuse, Cutaneous Mastocytosis
Author(s) -
Smith Michael L.,
Orton Paul W.,
Chu Henry,
Weston William L.
Publication year - 1990
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1990.tb01020.x
Subject(s) - cutaneous mastocytosis , medicine , dermatology , infiltration (hvac) , urticaria pigmentosa , pathology , disease , systemic mastocytosis , physics , thermodynamics
Diffuse, cutaneous mastocytosis is a rare variant of cutaneous mast cell infiltration that can arise in neonates or infants as a generalized bullous eruption. The mode of transmission is suggested as autosomal dominant. We report four infants from two unrelated families with diffuse cutaneous mastocytosis whose cutaneous disease was not controlled by initial therapies. Treatment of the four infants with photochemotherapy dramatically reduced or eliminated symptoms. One course of therapy resulted in improvement, and retreatment has not been required two to six years later.