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Fecal α 1 ‐Antitrypsin Concentration and Gastrointestinal Permeability to Oligosaccharides in Atopic Dermatitis
Author(s) -
Pike Michael G.,
Riches Pamela,
Atherton David J.
Publication year - 1989
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1989.tb00258.x
Subject(s) - medicine , atopic dermatitis , intestinal permeability , feces , gastroenterology , dermatology , immunology , microbiology and biotechnology , biology
Severe allergic protein‐losing enteropathy has been described in childhood atopic dermatitis (AD). Minor morphologic and functional abnormalities of the gastrointestinal mucosa, including altered permeability to oligosaccharides, are not uncommon in this condition, but the prevalence of occult enteric protein loss is unknown. We measured the random fecal α 1 ‐antitrypsin (AAT) concentration, an indicator of enteric protein loss, in children with and without AD and found no significant difference between the groups. In half of the patients with AD, gastrointestinal permeability to oligosaccharides was also measured, and no relationship between this and fecal AAT was found.