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Percutaneous Absorption of Hydrocortisone During and After the Acute Phase of Dermatitis in Children
Author(s) -
Turpeinen Markku,
LehtokoskiLehtiniemi Eeva,
Leisti Seppo,
Salo Osmo P.
Publication year - 1988
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1988.tb00904.x
Subject(s) - hydrocortisone , medicine , liter , absorption (acoustics) , percutaneous , anesthesia , dermatology , acoustics , physics
Percutaneous absorption of hydrocortisone was measured by a four hour absorption test in 16 children during and after the acute phase of dermatitis. In the acute phase, after the application of 1% hydrocortisone cream the increment in plasma cortisol ranged from 47 to 961 nmol per liter (median 248 nmol/L). After the acute phase the increment was significantly (P < 0.01< lower: range 18 to 241 nmol per liter (median 95 nmol/L). In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease. Convalescience is connected with a diminished systemic effect due to the restoration of the skin barrier to hydrocortisone.