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Sarcoidosis in Children: Differentiation from Juvenile Rheumatoid Arthritis
Author(s) -
Mallory Susan B.,
Paller Amy S.,
Ginsburg Barry C.,
McCrossin Ian D.,
Abernathy Rosalind
Publication year - 1987
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1987.tb00799.x
Subject(s) - medicine , sarcoidosis , juvenile rheumatoid arthritis , juvenile , rheumatoid arthritis , arthritis , dermatology , immunology , biology , genetics
Sarcoidosis is rare in young children. and is characterized by skin. joint. and eye changes. Differentiated clinically from juvenile rheumatoid ar‐ thritis (JRA) by milder constitutional symptoms and characteristic joint abnor‐ malities. sareoidosis is confirmed by demonstrating noncaseating granulomas in skin. conjunctival, or synovial biopsies. Recent reports have shown children with features of both sarcoidosis and juvenile rheumatoid arthritis. some with similarly affected family members. We cared for four children with sarcoidosis and severe joint manifestations. Two had a personal or family history of JRA. Three of the four children had ichthyosiform cutaneous manifestations. which may suggest an association between severe joint disease and ichthyosiform changes. Because of the difficulty in making a diagnosis on clinical grounds alone. biopsy of cutaneouslesions is recommended in children with these symptoms.