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Leiner's Disease Associated with Diminished Third Component of Complement
Author(s) -
Sonea Michael J.,
Moroz Brenda E.,
Reece Elena R.
Publication year - 1987
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1987.tb00762.x
Subject(s) - antibody opsonization , medicine , opsonin , immunology , complement (music) , concomitant , wasting , disease , diarrhea , antibody , biology , biochemistry , complementation , gene , phenotype
A 6‐week‐old female infant experienced recurrent diarrhea, wasting, and generalized seborrheic dermatitis. She manifested defective yeast opsonization and concomitant very low level of the third component of complement (C3). This is the first report of Leiners disease associated with diminished C3. It corroborates evidence to suggest that yeast opsonic activity of normal human serum is dependent on C3 levels.