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Chronic Bullous Dermatosis of Childhoo Immonopathologic Studies
Author(s) -
Roberts Lynne J.,
Sontheimer Richard D.
Publication year - 1987
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1987.tb00744.x
Subject(s) - dermoepidermal junction , medicine , direct fluorescent antibody , autoantibody , immunofluorescence , dermatology , indirect immunofluorescence , immunoglobulin a , antibody , pathology , immunology , immunoglobulin g , dermis
Chronic bullous dermatosis of childhood (CBDC) is a distinctive subepidermai olistenng disorder that characteristicaliy involves the lower Face, neck, lower trunk, and diaper area. Nearly ail affected patients have a conlinuous linear band of igA at the dermoepidermal junction by direct immunoflu‐orescence and many have circulating IgA antibasement membrane antibodies. Few uitrastructural studies have been performed to determine the location of these IgA autoantibodies. We examined an infant with the typical clinical, his‐topathologic. and immunopathologic features of CBDC in whom a circulating, lamina lucida‐reactive IgA autoantibody was identified wilh a new, more sensitive, split‐skin indirect immunofluorescence technique.