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Permethrin 1% Creme Rinse for the Treatment of Pediculus humanus var capitis Infestation
Author(s) -
Taplin David,
Meinking Terri L.,
Castiliero Pedro M.,
Sanchez Regulo
Publication year - 1986
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1986.tb00538.x
Subject(s) - permethrin , pediculosis , lindane , shampoo , medicine , placebo , dermatology , toxicology , infestation , pesticide , biology , pathology , botany , alternative medicine , agronomy
Permethrin 1% creme rinse (NIX) was tested as a treatment for Pediculus humanus var capitis (head lice) in a placebo‐controlled, double‐blinded, randomized study. As a positive control, a third arm of the study included nonrandomized, but investigator‐blinded, treatment with 1% lindane shampoo (Kwell). At 14 days after treatment, 97% of patients treated with permethrin were free of lice compared to 6% of placebo‐treated patients ( P < 0.001) and 43% of the lindane‐treated group. Permethrin was 70% ovicidal compared to 14% for placebo ( P < 0.001) and 45% for lindane. No adverse experiences were noted during this study. Permethrin 1% demonstrated high pediculicidal and ovicidal activities, which in combination with its low mammalian toxicity, residual activity, and cosmetic properties, make it an excellent treatment for pediculosis capitis.