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Waardenburg's Syndrome with Hirschsprung's Disease: A Neural Crest Defect
Author(s) -
Mallory Susan Bayliss,
Wiener Eugene,
Nordiund James J.
Publication year - 1986
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1986.tb00501.x
Subject(s) - medicine , neural crest , waardenburg syndrome , hirschsprung's disease , crest , megacolon , disease , dermatology , genetics , phenotype , biology , embryo , physics , gene , quantum mechanics
Waardenburg's syndrome and Hirschsprung's disease are both conditions involving a defect of migrating neural crest cells and may be seen together. We report a patient with the combination of these two diseases and review the literature on the subject. Physicians should be aware that deafness can be associated with pigmentary anomalies.