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Keratoderma Hereditaria Mutilans (Vohwinkel's Syndrome): A Trial of Isotretinoin
Author(s) -
Goldfarb Michael T.,
Woo Thomas Y.,
Rasmussen James E.
Publication year - 1985
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1985.tb01056.x
Subject(s) - medicine , isotretinoin , hyperkeratosis , keratoderma , dermatology , girl , pediatrics , palmoplantar keratoderma , acne , psychology , developmental psychology
An 8‐year‐old girl with the classic findings of keraloderma heredilaria mutilans (Vohwinkel's syndrome) was seen. Treatment with isotretinoin was instituted to decrease the hyperkeratosis and to prevent further autoamputation. After a 12‐week course at 2 mg per kg per day, the patient had only minimal decrease in the amount of hyperkeratosis. Because of Ihe well‐known long‐term risks of systematic retinoids and her suboptimal improvement, therapy was discontinued.