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Immunopathologic Demonstration of T Lymphocyte Subpopulations and Interleukin 2 in Graneloma Annulare
Author(s) -
Modlin Robert L.,
Horwitz David A.,
Jordan Robert R.,
Gebhard John F.,
Taylor Clive R.,
Rea Thomas H.
Publication year - 1984
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1111/j.1525-1470.1984.tb00437.x
Subject(s) - medicine , immunology , t lymphocyte , interleukin 2 , lymphocyte , interleukin , interleukin 4 , dermatology , cytokine , immune system
Immunopathologic aspects of granuloma annulare were studied in frozen sections of nine skin biopsy specimens with monoclonal antibodies directed against T lymphocytes, Langerhans'cells, interleukin 2, and interleukin 2 receptors in conjunction with immunoperoxidase techniques. The predominant lymphocyte was an activated T lymphocyte (Leu 1 + , HLA‐DR − ) with an excess of helper/inducer phenotype (Leu 3a + ) as compared with suppressor/cytotoxic phenotype (Leu 2a + ). Langerhans'cells were increased in the epidermis and numerous 0KT6 + cells were observed in the perivascular and granulomatous infiltrate. Both interleukin 2‐positive cells and interleukin 2 receptor‐positive cells were identified in the dermal lesions according to observed reactivity with the corresponding monoclonal antibodies. These findings suggest that a cell‐mediated immune response producing cytokines may be important in the pathogenesis of granuloma annulare. Comparison of theese results with skin specimens from patients with sarcoidosis and from a patient with granuloma annulare having some of the histologic features of sarcoidosis, suggests that the cutaneous infiltrate in granuloma annulare represents a response distinct from that of sarcoidosis.