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Low‐Efficiency Acute Renal Replacement Therapy: Role in Acute Kidney Injury
Author(s) -
Marshall Mark R.,
Golper Thomas A.
Publication year - 2011
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1111/j.1525-139x.2011.00829.x
Subject(s) - medicine , renal replacement therapy , dialysis , dosing , intensive care medicine , medical prescription , acute kidney injury , dialysis therapy , clinical trial , pharmacology
The methodology, prescription, and delivery of acute renal replacement therapy are rapidly evolving areas. Recent clinical trials have provided clearer guidance around dosing targets for both therapy prescription and delivery. In this article, we discuss dialysis efficiency which is an area that subserves dialysis dose and pertains to manner in which a given dose is delivered. Dialysis efficiency directly effects the measurement and calculation of dose, and the occurrence of dialysis disequilibrium and hemodynamic instability. We provide recommendations around selecting the most appropriate clinical scenario and patients for higher‐efficiency versus lower‐efficiency therapy, and the implementation of therapy to achieve a given efficiency.