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Innovation in the Treatment of Uremia: Proceedings from the Cleveland Clinic Workshop: Technical Approaches Toward Ambulatory ESRD Therapy
Author(s) -
Leonard Edward F.
Publication year - 2009
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1111/j.1525-139x.2009.00660.x
Subject(s) - medicine , ambulatory , intensive care medicine , continuous ambulatory peritoneal dialysis , dialysis , end stage renal disease , countercurrent exchange , hemodialysis , anatomy
Current efforts to prolong dialysis and make it ambulatory may, but need not, follow the established countercurrent contact of blood and dialysate through a membrane. Avoiding anticoagulation and addressing decremented performance of membranes used over long times suggests gentler blood contact and greatly reduced contact areas. This paper describes a microfluidic fluid‐to‐fluid contact system, still under development, and suggests that initial attempts at ambulatory support of end‐stage renal disease patients may be limited to interdialytic volume control, perhaps with a reduced frequency of dialysis which would then be used only to remove accumulated solutes.