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THE CLINICAL APPLICATION OF CRRT—CURRENT STATUS: Intensity of Continuous Renal Replacement Therapy in Acute Kidney Injury
Author(s) -
Palevsky Paul M.
Publication year - 2009
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1111/j.1525-139x.2008.00543.x
Subject(s) - medicine , renal replacement therapy , dosing , acute kidney injury , clinical trial , intensity (physics) , intensive care medicine , physics , quantum mechanics
The intensity of continuous renal replacement therapy (CRRT) is generally assessed on the basis of small solute clearance with dosing usually expressed in terms of total effluent volume per unit time (e.g., ml/kg/hour). Although several clinical trials have suggested an improvement in survival with higher doses of CRRT, results have not been consistent across all studies. The results of recent trials of intensity of CRRT are reviewed. The largest and most recent trials suggest that there is no additional benefit to using effluent flow rates in excess of 20 ml/kg/hour, although earlier studies suggested improved survival with doses of 35 to 45 ml/kg/hour.