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CARDIOVASCULAR AND SURVIVAL PARADOXES IN DIALYSIS PATIENTS: The Cholesterol Paradox Is Flawed; Cholesterol Must Be Lowered in Dialysis Patients
Author(s) -
Wan Ray K.,
Mark Patrick B.,
Jardine Alan G.
Publication year - 2007
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1111/j.1525-139x.2007.00359.x
Subject(s) - medicine , dyslipidemia , myocardial infarction , disease , dialysis , kidney disease , cholesterol , population , cardiology , malnutrition , atherosclerotic cardiovascular disease , intensive care medicine , environmental health
In the general population, elevated cholesterol is associated with cardiovascular disease and mortality and lowering cholesterol is associated with improved outcomes. This reflects the predominance of isolated atherosclerotic coronary disease in the general population. In patients with renal disease, however, the relationship between serum lipids and cardiovascular outcomes is much less clear and even reversed. In our opinion, the relationship between cholesterol and coronary disease is obscured by high levels of co‐morbid disease, malnutrition, inflammation, atypical dyslipidemia and the fact that myocardial infarction is not the typical presentation of cardiovascular disease in patients with renal disease. Thus, cholesterol lowering will still be effective in patients with chronic kidney diseases.