Open AccessRelationship Between Morning Hypertension Identified by Home Blood Pressure Monitoring and Brain Natriuretic Peptide and Estimated Glomerular Filtration Rate: The Japan Morning Surge 1 (JMS‐1) Study
Author(s) -
Ishikawa Joji,
Hoshide Satoshi,
Shibasaki Seiichi,
Matsui Yoshio,
Kabutoya Tomoyuki,
Eguchi Kazuo,
Ishikawa Shizukiyo,
Pickering Thomas G.,
Shimada Kazuyuki,
Kario Kazuomi
Publication year - 2008
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1524-6175.2007.07250.x
Subject(s) - medicine , morning , blood pressure , evening , left ventricular hypertrophy , cardiology , brain natriuretic peptide , renal function , ambulatory blood pressure , confounding , natriuretic peptide , endocrinology , heart failure , physics , astronomy
We evaluated whether morning minus evening systolic blood pressure (SBP) difference (MEdif) in home blood pressure measurements can be a marker for hypertensive target organ damage. The authors analyzed 611 hypertensive patients who had high morning SBP levels (≥135 mm Hg). The patients with morning hypertension (MEdif ≥15 mm Hg, average of morning and evening SBP [MEave] ≥135 mm Hg) were older ( P <.001) and had a longer duration of hypertension and antihypertensive medication use, a higher prevalence of left ventricular hypertrophy (LVH) on electrocardiography, a lower glomerular filtration rate by the Cockcroft‐Gault equation ( P =.002), and a higher brain natriuretic peptide (BNP) level ( P <.001) than those with well‐controlled blood pressure (MEdif <15 mm Hg, MEave <135 mm Hg). The patients with morning hypertension had a higher BNP level than those with well‐controlled blood pressure after adjustment for the confounding factors (28.7 pg/mL vs 20.0 pg/mL; P=.033). In conclusion, morning hypertension is more likely seen among patients with older age and longer duration of hypertension and antihypertensive medication use, and it may be associated with a higher prevalence of LVH and a higher BNP level .