Open AccessEffects of Warfarin on Blood Pressure in Men With Diabetes and Hypertension—A Longitudinal Study
Author(s) -
Lim Mary Ann,
Shafique Shahzad,
See Sein Yin,
Khan Faisal N.,
Parikh Chirag R.,
Peixoto Aldo J.
Publication year - 2007
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1524-6175.2007.06383.x
Subject(s) - medicine , blood pressure , diabetes mellitus , warfarin , cardiology , endocrinology , atrial fibrillation
Warfarin causes extensive vascular calcification leading to increased systolic blood pressure and pulse pressure in rats, may be associated with increased valvular and coronary calcifications in man, and possibly worsens hypertension in high‐risk patients, particularly in those with diabetes mellitus or uncontrolled hypertension. The authors evaluated blood pressure and intensity of antihypertensive therapy over 36 months in a cohort of 58 patients with diabetes and hypertension on warfarin and 58 control subjects with diabetes and hypertension not on warfarin. The results demonstrate that warfarin therapy at conventional doses does not increase systolic blood pressure or pulse pressure in patients with diabetes and hypertension.