Open AccessHypertension and Kidney Damage
Author(s) -
Griffin Karen A.,
Bidani Anil K.
Publication year - 2006
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1524-6175.2005.05111.x
Subject(s) - medicine , blood pressure , kidney disease , hypertensive nephropathy , blockade , kidney , renal injury , disease , nephropathy , diabetic nephropathy , renin–angiotensin system , cardiology , endocrinology , diabetes mellitus , receptor
Substantial evidence indicates that hypertension is a major contributor to the development of end‐stage renal disease in most patients. However, such risk ranges from being fairly low in essential hypertension to a marked increase in susceptibility to hypertensive injury in patients with chronic kidney disease, including diabetic nephropathy. Studies in experimental animal models using blood pressure radiotelemetry have provided significant insights into the quantitative relationships between blood pressure and renal damage and the importance of protective renal autoregulatory capacity as a determinant of such differences in susceptibility to hypertensive injury. Moreover, such investigations have also emphasized the predominant importance of achieving normotension per se over the selection of particular antihypertensive regimens, including renin–angiotensin system blockade, in slowing the progression of chronic kidney disease.