Open AccessThiazide‐Type Diuretics: Ongoing Considerations on Mechanism of Action
Author(s) -
Sica Domenic A.
Publication year - 2004
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1524-6175.2004.03902.x
Subject(s) - medicine , thiazide , action (physics) , mechanism (biology) , mechanism of action , pharmacology , diuretic , epistemology , philosophy , physics , quantum mechanics , biochemistry , chemistry , in vitro
Thiazide‐type diuretics have enjoyed a considerable success in the management of hypertension. These drugs have assumed a standard‐of‐care position in the minds of many health care providers; however, a number of questions remain unresolved in relation to their use. Such questions include issues of mechanism of action, comparability to loop‐diuretics in their actions, class‐effect, and the basis for their additivity with non‐diuretic antihypertensive medication classes. Understanding these issues is important to the effective use of these compounds.