Open AccessElevation of C‐Reactive Protein in People With Prehypertension
Author(s) -
King Dana E.,
Egan Brent M.,
Mainous Arch G.,
Geesey Mark E.
Publication year - 2004
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1524-6175.2004.03577.x
Subject(s) - medicine , prehypertension , odds ratio , confidence interval , national health and nutrition examination survey , blood pressure , body mass index , confounding , c reactive protein , diabetes mellitus , diastole , cardiology , endocrinology , environmental health , population , inflammation
The objective of this study was to determine the relationship of C‐reactive protein (CRP) and blood pressure (BP) across the range of BP categories including prehypertension. The Third National Health and Nutrition Examination Survey (NHANES III) data collected from 1988 to 1994 were analyzed. In unadjusted analyses, there was a step‐wise increase in the probability of elevated CRP across a wide range of BP categories. Prehypertensive participants had a higher prevalence of elevated CRP than normotensive people (27.4% vs. 19.8%; p <05). After adjustment for age, gender, race, smoking, body mass index, exercise, diabetes, and medication usage, participants with systolic BP 120–139 mm Hg or diastolic BP 80–89 mm Hg were more likely to have elevated CRP than people with systolic BP <120 (odds ratio, 1.36; 95% confidence interval, 1.14–1.62; odds ratio, 1.20; 95% confidence interval, 1.02–1.41, respectively). CRP and BP are positively related across a wide range of BP categories. A substantial proportion of prehypertensive individuals have elevated CRP independent of multiple confounders.