Open AccessTherapeutic Considerations in the Treatment of Obesity Hypertension
Author(s) -
Wofford Marion R.,
Miller Davis Margaret,
Harkins Kimberly G.,
King Deborah S.,
Wyatt Sharon B.,
Jones Daniel W.
Publication year - 2002
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1524-6175.2002.00502.x
Subject(s) - medicine , blood pressure , obesity , pharmacotherapy , weight loss , disease , clinical trial , intensive care medicine , risk factor , lifestyle modification
Obesity, now recognized as an independent risk factor for cardiovascular disease, is closely associated with hypertension. Complex mechanisms link increasing body weight with increasing blood pressure. Treatment of the obese patient with hypertension requires consideration of physiologic changes related to obesity hypertension. Lifestyle modification, including weight reduction and increased physical activity, can directly influence blood pressure levels and improve blood pressure control in obese, hypertensive patients. Clinical trials are needed to determine the most effective antihypertensive drugs for the obese, hypertensive patient. Antiobesity drugs offer viable adjunctive pharmacotherapy for obesity hypertension, but additional long‐term studies are needed to support their safety and efficacy.