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Mathematical modeling of venous ulcer healing rates after implantation of keratinocytes: New ways to predict the efficacy of wound healing after regenerative methods
Author(s) -
Renner Regina,
Simon Jan C.
Publication year - 2010
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1524-475x.2010.00627.x
Subject(s) - wound healing , medicine , surgery , artificial skin
The treatment of patients with leg ulcers is both time consuming as well as costly. We found predictable and objective parameters with a mathematical model, which will help to assess wound healing in an individual. The basic principle of our mathematic model is that cells of the neoepithelium are under the influence of different stress factors. We identified correlations between the parameters of our equation and the ulcer area and ulcer duration, based on wound size reduction by a new epithelial layer, and we estimated the survival rates of the transplanted keratinocytes. Our model is consistent with our clinical data and seems applicable for analogous situations, e.g., transplantations of cells to wounds. By this method, we are able to compare qualitatively different treatments and different materials for wound healing even in small groups of patients in an objective way.