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Donor site wound protein synthesis correlates with length of acute hospitalization in severely burned children
Author(s) -
Tuvdendorj Demidmaa,
Chinkes David L.,
Zhang XiaoJun,
Aarsland Asle,
Herndon David N.
Publication year - 2010
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1524-475x.2010.00584.x
Subject(s) - total body surface area , medicine , body surface area , burn wound , wound healing , severe burn , surgery , population , environmental health
Autografting of burn wounds results in generation of donor site wounds. Here we measured donor site wound protein fractional synthesis rate (FSR) in a burn pediatric population and showed that FSR increases over time postsurgery and correlates with the length of hospital stay (LOS) normalized for total body surface area (TBSA) burn size. 3.9 ± 1.1 days after the grafting surgery patients participated in a metabolic study consisting of continuous infusion of l ‐[ring‐ 2 H 5 ]‐phenylalanine and donor site wound punch biopsies. Donor site wound protein FSR was 10.4 ± 7.5%/day. Wound FSR demonstrated linear correlation with the time postsurgery ( p <0.05). Multiple regression analysis showed that LOS/TBSA correlated with donor site wound protein FSR and time postsurgery ( p <0.001) and the following equation describes the relationship: estimated LOS/TBSA=(FSR−12.95−1.414 × postsurgery day)/(−17.8). This equation predicted that FSR corrected for the postsurgery day when the metabolic study was conducted accounted for 67% of the variability ( r 2 =0.673) in the LOS/TBSA. Donor site wound protein FSR correlated to LOS/TBSA of burn patients admitted to the intensive care unit. Measurement of protein deposition in regenerating donor site wound using stable isotope technique provides a quantitative measure of wound healing.