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Molecular mechanisms of enhanced wound healing by copper oxide‐impregnated dressings
Author(s) -
Borkow Gadi,
Gabbay Jeffrey,
Dardik Rima,
Eidelman Arthur I.,
Lavie Yossi,
Grunfeld Yona,
Ikher Sergey,
Huszar Monica,
Zatcoff Richard C.,
Marikovsky Moshe
Publication year - 2010
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1524-475x.2010.00573.x
Subject(s) - wound healing , angiogenesis , extracellular matrix , vascular endothelial growth factor , copper , growth factor , chemistry , medicine , pharmacology , surgery , vegf receptors , cancer research , biochemistry , receptor , organic chemistry
Copper plays a key role in angiogenesis and in the synthesis and stabilization of extracellular matrix skin proteins, which are critical processes of skin formation. We hypothesized that introducing copper into wound dressings would enhance wound repair. Application of wound dressings containing copper oxide to wounds inflicted in genetically engineered diabetic mice (C57BL/KsOlaHsd‐Lepr db ) resulted in increased gene and in situ up‐regulation of proangiogenic factors (e.g., placental growth factor, hypoxia‐inducible factor‐1 alpha, and vascular endothelial growth factor), increased blood vessel formation ( p <0.05), and enhanced wound closure ( p <0.01) as compared with control dressings (without copper) or commercial wound dressings containing silver. This study proves the capacity of copper oxide‐containing wound dressings to enhance wound healing and sheds light onto the molecular mechanisms by which copper oxide‐impregnated dressings stimulate wound healing.