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Enhanced healing of mitomycin C‐treated wounds in rats using inbred adipose tissue‐derived stromal cells within an atelocollagen matrix
Author(s) -
Nambu Masaki,
Ishihara Masayuki,
Nakamura Shingo,
Mizuno Hiroshi,
Yanagibayashi Satoshi,
Kanatani Yasuhiro,
Hattori Hidemi,
Takase Bonpei,
Ishizuka Takamitsu,
Kishimoto Satoko,
Amano Yoshiko,
Yamamoto Naoto,
Azuma Ryuichi,
Kiyosawa Tomoharu
Publication year - 2007
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1524-475x.2007.00258.x
Subject(s) - granulation tissue , mitomycin c , wound healing , adipose tissue , medicine , stromal cell , extracellular matrix , mesenchymal stem cell , surgery , pathology , chemistry , biochemistry
The aim of this study was to evaluate the potential accelerating effects of an adipose tissue‐derived stromal cells (ATSC)‐containing atelocollagen matrix with silicone membrane (ACMS) for repairing mitomycin C‐treated healing‐impaired wounds. Mitomycin C was applied to full‐thickness skin incisions in this study to create a healing‐impaired wound model in rat. After thoroughly washing out the mitomycin C from the wound, ACMS alone or ATSC‐containing ACMS was applied to the wounds. Histological sections of the wounds were then prepared at indicated time periods after the treatments. These results indicated significantly advanced granulation tissue and capillary formations in the healing‐impaired wounds treated with ATSC‐containing ACMS compared with those treated with ACMS alone. Thus, this study suggested that transplantation of inbred ATSC‐containing ACMS is effective for repairing healing‐impaired wounds.