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A silicone‐based controlled‐release device for accelerated proteolytic debridement of wounds
Author(s) -
Bott Richard,
Crissman James,
Kollar Csilla,
Saldajeno Mae,
Ganshaw Grant,
Thomas Xavier,
Lane Thomas H.,
Klykken Paal,
Davidson Jeffrey M.,
Nanney Lillian B.
Publication year - 2007
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/j.1524-475x.2007.00209.x
Subject(s) - eschar , debridement (dental) , subtilisin , wound healing , proteolytic enzymes , silicone , emulsion , collagenase , surgery , medicine , granulation tissue , chemistry , enzyme , biochemistry , organic chemistry
A new device for rapid enzymatic debridement of cutaneous wounds has been developed using a controlled‐release, silicone‐based, dried emulsion. A dehydrated serine protease of the subtilisin family, previously untested for wound debridement, was incorporated into the emulsion. This device exhibited excellent storage stability. Moisture from the wound triggered an even, reproducible, and complete release of the enzyme within the first 8 hours. The device maintains a moist wound environment that allows the enzyme to achieve nearly complete digestion of the hardened eschar of full‐thickness burns in a porcine model after an exposure period of 24 hours. Debridement was faster than in untreated wounds or wounds treated with a currently available enzyme ointment. Following rapid enzymatic debridement, healing appeared to progress normally, with no histological evidence of damage to adjacent healthy tissue.