Open AccessPseudoangiomatous Stromal Hyperplasia. A Case for Bilateral Mastectomy in a 12‐Year‐Old Girl
Author(s) -
Singh Kimberly A.,
Lewis Melinda M.,
Runge Robyn L.,
Carlson Grant W.
Publication year - 2007
Publication title -
the breast journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 72
eISSN - 1524-4741
pISSN - 1075-122X
DOI - 10.1111/j.1524-4741.2007.00499.x
Subject(s) - medicine , girl , mastectomy , breast enlargement , stromal cell , gynecomastia , hyperplasia , surgery , right breast , radiology , pathology , breast cancer , cancer , psychology , developmental psychology
Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferation of breast stromal cells with a complex pattern of interanastomosing spaces lined by myofibroblasts and is most commonly seen in women of child‐bearing age. PASH is a frequent incidental microscopic finding in breast biopsies. Nodular PASH, however, resulting in a clinically appreciable mass and rapid growth is a rare entity, with only four such patients cited in the literature. Surgical excision results in a cure in the majority of cases, with a recurrence rate of approximately 7–22%. We report a case of a 12‐year‐old girl with nodular PASH who presented with bilateral breast enlargement refractory to surgical excisions, eventually requiring bilateral mastectomies. To our knowledge, our patient is the youngest patient to have nodular PASH and to undergo bilateral mastectomies.