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Observation of Gastric Mucosa in B angladesh, the Country with the Lowest Incidence of Gastric Cancer, and J apan, the Country with the Highest Incidence
Author(s) -
Matsuhisa Takeshi,
Aftab Hafeza
Publication year - 2012
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/j.1523-5378.2012.00967.x
Subject(s) - incidence (geometry) , cancer , gastroenterology , food science , medicine , traditional medicine , chemistry , mathematics , geometry
Background The prevalence of H elicobacter pylori ( H . pylori ) infection is high, but the incidence of gastric cancer is low in natives of B angladesh. The gastric mucosa was observed in B angladeshi patients to investigate the differences between B angladeshis and J apanese. Materials and Methods The study involved 418 B angladeshi and 2356 J apanese patients with abdominal complaints who underwent endoscopy examinations and had no history of H . pylori eradication. The prevalence of H . pylori infection and the gastric mucosa in H . pylori ‐positive patients were compared between age‐, gender‐, and endoscopic diagnosis‐matched B angladeshi and J apanese subjects. Results The prevalence of H . pylori infection was higher in B angladeshi than in J apanese subjects (60.2 and 45.1%, respectively). All the scores for chronic inflammation, neutrophil activity, glandular atrophy, and intestinal metaplasia were significantly lower in H . pylori‐ positive B angladeshis than in H . pylori‐ positive J apanese. The ratio of the corpus gastritis score ( C ) to the antrum gastritis score ( A ) ( C/A ratio) was <1 (antrum‐predominant gastritis) in all age groups of B angladeshi subjects, whereas the C/A ratio changed from <1 to more than 1 (corpus‐predominant gastritis) with aging in J apanese subjects. Conclusions The scores for glandular atrophy and intestinal metaplasia in H . pylori‐ positive B angladeshis were significantly lower than those in J apanese. All age groups of B angladeshis had antrum‐predominant gastritis, whereas corpus‐predominant gastritis was more common than antrum‐predominant gastritis in older J apanese age groups. These results may explain the low incidence of gastric cancer in B angladeshis and the high incidence in J apanese.