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Genetic Variation in a4GnT in Relation to Helicobacter pylori Serology and Gastric Cancer Risk
Author(s) -
Zheng Zongli,
Jia Yanbin,
Hou Lifang,
Persson Christina,
Yeager Meredith,
Lissowska Jolanta,
Chanock Stephen J.,
Blaser Martin,
Chow WongHo,
Ye Weimin
Publication year - 2009
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/j.1523-5378.2009.00708.x
Subject(s) - helicobacter pylori , odds ratio , haplotype , cancer , serology , biology , medicine , gastroenterology , genetic variation , stomach cancer , population , locus (genetics) , immunology , genotype , genetics , gene , antibody , environmental health
Background: Helicobacter pylori, a known risk factor of gastric cancer, rarely colonize the deeper portion of normal gastric glands, where the mucus is rich in α‐1,4‐linked N ‐acetylglucosamine capped O ‐glycans, that strongly inhibit H. pylori growth in vitro . Materials and methods: We investigated the association between genetic variation in the O ‐glycan transferase encoding gene ( a4GnT ) and H. pylori infection and gastric cancer risk using a Polish population‐based case–control study (273 gastric cancer patients and 377 controls). Results: A haplotype at the rs2622694–rs397266 locus was associated with H. pylori infection, with the A‐A haplotype associated with a higher risk compared with the most frequent G‐G haplotype (odds ratio 2.30; 95% confidence interval 1.35–3.92). The association remained significant after correction for multiple tests (global p value: nominal 0.002, empirical 0.045). Neither this haplotype nor the tagSNPs were associated with overall gastric cancer risk. Conclusion: a4GnT genetic variation may be relevant to H. pylori infection, but not to gastric cancer risk.