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Eradication of Helicobacter pylori Infection Equally Improves Chronic Urticaria With Positive and Negative Autologous Serum Skin Test
Author(s) -
Magen Eli,
Mishal Joseph,
Schlesinger Menachem,
Scharf Shimon
Publication year - 2007
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/j.1523-5378.2007.00522.x
Subject(s) - helicobacter pylori , omeprazole , medicine , gastroenterology , clarithromycin , amoxicillin , urea breath test , chronic urticaria , group b , breath test , group a , helicobacter pylori infection , antibiotics , microbiology and biotechnology , biology
Background: The aim of the study was to examine effects of Helicobacter pylori eradication on chronic idiopathic urticaria (CU) with and without positive aulogous serum skin test (ASST). Methods: Seventy‐eight patients with CU were checked for the positivity ASST and H. pylori urea 13 C‐urea breath test ( 13 C‐UBT). Twenty‐one patients were with both positive ASST and positive 13 C‐UBT (group A), and 24 patients were with negative ASST and positive 13 C‐UBT (group B). All patients with positive 13 C‐UBT received a 14‐day, open treatment with amoxicillin 1 g b.i.d., clarithromycin 500 mg b.i.d., and omeprazole 20 mg b.i.d. H. pylori eradication was assessed by a second 13 C‐UBT after 8 weeks. In control group, 33 patients with CU were included. The effect of H. pylori eradication on CU was evaluated by urticaria activity score (UAS), measured at study entry and at 8 and 16 weeks. Results: At week 8, baseline UAS reduced from 4.7 ± 1.1 to 2.4 ± 1.4 ( p = .027) in group A and from 4.3 ± 1.5 to 2.3 ± 1.2 ( p = .008) in group B, without statistically significant difference between the two groups. In control group and in six patients with H. pylori eradication failure, no changes of UAS were noted. Conclusion: Eradication of H. pylori infection by triple therapy significantly and equally reduces UAS in CU patients with positive and negative ASST.