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Helicobacter pylori Colonization in the First 3 Years of Life in Japanese Children
Author(s) -
Okuda Masumi,
Miyashiro Eikichi,
Booka Mina,
Tsuji Tomomi,
Nakazawa Teruko
Publication year - 2007
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/j.1523-5378.2007.00510.x
Subject(s) - helicobacter pylori , colonization , medicine , optical density , pediatrics , false positive paradox , prospective cohort study , helicobacter pylori infection , gastroenterology , biology , microbiology and biotechnology , machine learning , computer science , ophthalmology
Abstract Background: Acquisition of Helicobacter pylori infection occurs in early childhood, but the exact time of the acquisition and dynamics of infection are not clear. The aim of this study was to estimate the time of acquisition of H. pylori colonization in infants. Subjects and methods: This prospective follow‐up study included 237 infants born in Wakayama Rosai Hospital from February, 2001 to April, 2002. Stool samples were collected at indicated ages, and H. pylori antigens were determined by a stool antigen test, HpSA. Results: One‐hundred and eight infants among initially enrolled 237 children have been followed up until 24 months. Among these, 16 infants turned to be HpSA positive within 12 months, but only four remained positive by the consecutive tests with optical density values of more than 0.7. They were assumed persistent positives. The rest 12 infants reverted to be negative by the consecutive tests and were assumed transient or false‐positives. The optical density values of HpSA in the transient cases were exclusively less than 0.35. Conclusions: The consecutive follow up of HpSA, but not the one‐point test, might be useful to diagnose persistent colonization of H. pylori in young infants, and some infants seemed to acquire H. pylori infection in the first year of life. These results should be taken into account for prevention and treatment strategies for H. pylori infection in infants.