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Helicobacter pylori , Ethnicity, and the Gastroesophageal Reflux Disease Spectrum: A Study from the East
Author(s) -
Rajendra Shanmugarajah,
Ackroyd Roger,
Robertson Iain K.,
Ho Jacqueline J.,
Karim Norain,
Kutty Kannan M.
Publication year - 2007
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/j.1523-5378.2007.00489.x
Subject(s) - gerd , caga , helicobacter pylori , gastroenterology , medicine , esophagus , reflux , disease , gastritis , biology , biochemistry , virulence , gene
Background: Ethnic differences in gastroesophageal reflux disease (GERD) and its complications as well as racial variations in the prevalence of Helicobacter pylori infection are well documented. Nevertheless, the association between reflux disease, H. pylori , and race has not been adequately explored. Aims: We estimated the strength of the association between H. pylori , ethnicity, and the gastroesophageal reflux disease (GERD) spectrum, including Barrett's esophagus, in Asian patients presenting for endoscopy in a tertiary referral center. Methods: Prospectively, we studied 188 consecutive patients with GERD, short‐ and long‐segment Barrett's esophagus, and controls. All patients underwent gastroscopy with gastric biopsies to assess H. pylori , gastritis, and atrophy. CagA status and H. pylori infection were determined by immunoblot assay. Results: The overall prevalence of H. pylori infection was 52.1% (of which 77.6% were cagA + ) and was lowest in the long‐segment Barrett's esophagus group (36.7%) ( p = .048). When Barrett's esophagus was present, the length of abnormality was 44.8% shorter in the presence of H. pylori ( p = .015). Indians had the highest prevalence of H. pylori (75%) and Malays the lowest (19.6%) ( p < .001). In Indians, increased prevalence of H. pylori and cagA ‐positive strains was associated with reduced severity of GERD ( p < .004 and p < .001, respectively), a trend not apparent in the other races. Corpus atrophy, which was almost exclusively associated with H. pylori , was highest in Indians as compared to the other races ( p = .013). Conclusions: Presence of H. pylori was associated with a reduced severity of GERD spectrum disease in Asians, especially Indians. H. pylori infection may protect against complicated reflux disease via induction of corpus atrophy.