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VacA‐Associated Inhibition of T‐cell Function: Reviewed and Reconsidered
Author(s) -
Schmees Christian,
Gerhard Markus,
Treptau Tilman,
Voland Petra,
Schwendy Susanne,
Rad Roland,
Prinz Christian
Publication year - 2006
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/j.1523-5378.2006.00393.x
Subject(s) - immune system , bacteria , microbiology and biotechnology , helicobacter pylori , infiltration (hvac) , immunology , in vitro , cell , biology , phagocytosis , toxin , genetics , materials science , composite material
Chronic Helicobacter pylori infection is characterized by dense infiltration of the mucosa with neutrophilic granulocytes, lymphocytes, and monocytes/macrophages. Among these different cell types, T‐lymphocytes are the most intriguing and crucial cells for the elimination of the bacteria. Previous studies have elucidated possible mechanisms on how bacteria could interfere with the human immune response and claimed that especially the secreted vacuolating toxin VacA may be responsible for the chronic persistence of the bacteria. Some of these results have to be interpreted with caution and may just describe in vitro phenomena; others may reveal promising facts.