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Long‐Term Follow‐up after Eradication of Helicobacter pylori with Omeprazole, Clarithromycin, and Tinidazole (OCT Regimen) in a Japanese Population
Author(s) -
Ando Takafumi,
Minami Masaaki,
Mizuno Tomokazu,
Watanabe Osamu,
Ishiguro Kazuhiro,
Ina Kenji,
Kusugami Kazuo,
Nobata Kazuo,
Nishiwaki Tsuyoshi,
Tsuzuki Tomoyuki,
Shimada Masaaki,
ElOmar Emad,
Goto Hidemi
Publication year - 2005
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/j.1523-5378.2005.00344.x
Subject(s) - helicobacter pylori , tinidazole , omeprazole , medicine , clarithromycin , gastroenterology , rapid urease test , metronidazole , urea breath test , regimen , amoxicillin , population , breath test , peptic , proton pump inhibitor , gastritis , surgery , peptic ulcer , antibiotics , helicobacter pylori infection , microbiology and biotechnology , environmental health , biology
Background. The long‐term benefit of Helicobacter pylori eradication treatment that includes metronidazole on peptic ulcer disease in Japan is unclear. We investigated the rate of H. pylori re‐infection and ulcer relapse after H. pylori eradication. Materials and methods. A total of 266 patients with endoscopically confirmed peptic ulcer disease and H. pylori infection were treated with triple therapy of omeprazole 40 mg (20 mg b.i.d.), clarithromycin 800 mg (400 mg b.i.d.), and tinidazole 1000 mg (500 mg b.i.d.) for 7 days. Endoscopy with gastric biopsy was performed before and 1 month, 6 months, 1.5 years, and 3.5 years after therapy. H. pylori status was determined by H. pylori culture, rapid urease test, and histopathology. 13 C‐urea breath test was done at 6 months after eradication therapy. Treatment was deemed successful when all tests were negative at 6 months after therapy by endoscopic biopsy. Results. Successful H. pylori eradication was achieved in 262/266 (98.5%) patients with peptic ulcer. Total relapse of peptic ulcer occurred in 8/262 (3%) patients after eradication, with 3/262 (1.1%) occurring within 1.5 years after treatment and 5/262 (1.9%) within 3.5 years. All relapsed patients were found to be H. pylori ‐positive at the time of relapse. Of the 262 patients who experienced eradication, 20 (7.6%) were subsequently re‐infected, six (2.3%) within 1.5 years and 14 (5.3%) within 3.5 years. Conclusion. Triple therapy with omeprazole, clarithromycin, and tinidazole (OCT) is useful for H. pylori eradication in Japan, but there is an appreciable re‐infection rate in this population.